Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967270 | 0.89 | KDM4E (0.39) | CCR5ROS1KLKB1SMN1; SMN2MAP4K1 | |
| SCHEMBL14967406 | 0.88 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL14966658 | 0.88 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL14967419 | 0.88 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL14967264 | 0.87 | SMN1; SMN2 (0.42) | CCR5SMN1; SMN2ROCK2ROCK1NPC1 | |
| SCHEMBL14966473 | 0.86 | MAPK14 (0.42) | CCR5ROS1KLKB1SMN1; SMN2EZH2 | |
| SCHEMBL14966798 | 0.86 | KLKB1 (0.44) | CCR5KLKB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14972144 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9APOLBHPGD | |
| SCHEMBL14966828 | 0.85 | SMN1; SMN2 (0.41) | CCR5KLKB1SMN1; SMN2MAP4K1KDM4E | |
| SCHEMBL14966873 | 0.85 | KLKB1 (0.39) | CCR5ROS1KLKB1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |