Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969773 | 0.92 | PPARA (0.45) | SMN1; SMN2MAPK14CYP3A4POLBNPC1 | |
| SCHEMBL14969416 | 0.92 | PPARA (0.45) | SMN1; SMN2MAPK14CYP3A4POLBNPC1 | |
| SCHEMBL14966982 | 0.92 | PPARA (0.45) | SMN1; SMN2MAPK14CYP3A4POLBNPC1 | |
| SCHEMBL14967406 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPK14POLBRAB9AALDH1A1 | |
| SCHEMBL14966658 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPK14POLBRAB9AALDH1A1 | |
| SCHEMBL14967419 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPK14POLBRAB9AALDH1A1 | |
| SCHEMBL14967264 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2MMP13MAPK14CYP3A4MMP2 | |
| SCHEMBL14966798 | 0.90 | KLKB1 (0.44) | SMN1; SMN2MMP13MAPK14HTTPOLB | |
| SCHEMBL14967253 | 0.89 | MEN1 (0.41) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL14966828 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |