Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 4/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 5/20 | 0.34 |
| ▸ | CA1 | P00915 | 5/20 | 0.34 |
| ▸ | CA2 | P00918 | 5/20 | 0.34 |
| ▸ | CA9 | Q16790 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29707372 | 0.85 | AAK1 (0.47) | AAK1IDO1NQO2MEN1GAA | |
| SCHEMBL14966705 | 0.78 | SYK (0.41) | AAK1PARP1CKS1BSKP1SKP2 | |
| SCHEMBL25574990 | 0.77 | AAK1 (0.49) | AAK1IDO1CA12CA1CA2 | |
| SCHEMBL14966586 | 0.76 | AAK1 (0.45) | AAK1PARP1CKS1BSKP1SKP2 | |
| SCHEMBL19244825 | 0.75 | LMNA (0.47) | CKS1BSKP1SKP2IDO1NQO2 | |
| SCHEMBL18342083 | 0.73 | MEN1 (0.46) | CKS1BSKP1SKP2IDO1MEN1 | |
| SCHEMBL21710422 | 0.72 | AAK1 (0.46) | AAK1IDO1MEN1GAAKMT2A | |
| SCHEMBL20500778 | 0.71 | TDP1 (0.54) | CKS1BSKP1SKP2IDO1MEN1 | |
| SCHEMBL22664847 | 0.70 | AAK1 (0.45) | AAK1IDO1NQO2CA12CA1 | |
| SCHEMBL29533276 | 0.70 | AAK1 (0.45) | AAK1IDO1NQO2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |