Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966545 | 0.91 | KLKB1 (0.41) | KLKB1LMNARECQLKMT2APOLB | |
| SCHEMBL14972131 | 0.82 | POLB (0.43) | TSHRKLKB1LMNARECQLKMT2A | |
| SCHEMBL14966659 | 0.78 | LMNA (0.48) | KLKB1LMNAKMT2APOLBMEN1 | |
| SCHEMBL14967113 | 0.78 | LMNA (0.50) | TSHRLMNARECQLMMP13GAA | |
| SCHEMBL14966827 | 0.77 | SMN1; SMN2 (0.43) | KLKB1LMNARECQLKMT2APOLB | |
| SCHEMBL14966404 | 0.77 | KLKB1 (0.41) | KLKB1ALDH1A1HTT | |
| SCHEMBL14966398 | 0.76 | POLB (0.52) | KLKB1LMNAKMT2APOLBALDH1A1 | |
| SCHEMBL14966965 | 0.76 | NPC1 (0.47) | KLKB1LMNAKMT2AMEN1 | |
| SCHEMBL14967152 | 0.75 | KDM4E (0.43) | KLKB1LMNAKMT2AALDH1A1HTT | |
| SCHEMBL14966625 | 0.75 | SMN1; SMN2 (0.43) | KLKB1LMNAKMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |