Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966641 | 0.88 | SMN1; SMN2 (0.40) | KLKB1MAPTSMN1; SMN2TP53 | |
| SCHEMBL14967162 | 0.88 | SMN1; SMN2 (0.40) | KLKB1MAPTSMN1; SMN2TP53 | |
| SCHEMBL14967484 | 0.88 | SMN1; SMN2 (0.40) | KLKB1MAPTSMN1; SMN2TP53 | |
| SCHEMBL14969791 | 0.81 | TDP1 (0.39) | KLKB1MAPTSMN1; SMN2ROS1LMNA | |
| SCHEMBL14969477 | 0.81 | TDP1 (0.39) | KLKB1MAPTSMN1; SMN2ROS1LMNA | |
| SCHEMBL14966934 | 0.81 | TDP1 (0.39) | KLKB1MAPTSMN1; SMN2ROS1LMNA | |
| SCHEMBL14967045 | 0.80 | SMN1; SMN2 (0.41) | KLKB1MAPTSMN1; SMN2TP53LMNA | |
| SCHEMBL14966826 | 0.80 | SMN1; SMN2 (0.41) | KLKB1MAPTSMN1; SMN2TP53LMNA | |
| SCHEMBL14966473 | 0.78 | MAPK14 (0.42) | KLKB1MAPTSMN1; SMN2TP53ROS1 | |
| SCHEMBL14967281 | 0.78 | KDM4E (0.41) | KLKB1MAPTSMN1; SMN2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |