Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422047 | 0.98 | KMT2A (0.49) | KMT2ACYSLTR2SRD5A2HRH3MEN1 | |
| SCHEMBL14966696 | 0.85 | KMT2A (0.40) | KMT2AHRH3MEN1PDE4APDE4B | |
| SCHEMBL1750552 | 0.84 | KMT2A (0.54) | KMT2ASRD5A2MEN1EPHX2EPHX1 | |
| SCHEMBL14967373 | 0.84 | CYP4A11 (0.51) | KMT2AMEN1EPHX2EPHX1ALDH1A1 | |
| SCHEMBL1749785 | 0.82 | KMT2A (0.51) | KMT2ASRD5A2EPHX1PDE4APDE4B | |
| SCHEMBL1422283 | 0.82 | CYP4A11 (0.53) | KMT2AMEN1EPHX2EPHX1ALDH1A1 | |
| SCHEMBL10455058 | 0.80 | ESR1 (0.45) | KMT2AALDH1A1 | |
| SCHEMBL7455241 | 0.80 | TAAR1 (0.46) | HRH3EPHX2 | |
| SCHEMBL873249 | 0.80 | TAAR1 (0.46) | HRH3EPHX2 | |
| SCHEMBL14966922 | 0.80 | PDE4D (0.45) | KMT2AHRH3MEN1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |