Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.45 |
| ▸ | PDE4A | P27815 | 7/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966696 | 0.92 | KMT2A (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL14966656 | 0.85 | CYP4A11 (0.47) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1422047 | 0.81 | KMT2A (0.49) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL14967005 | 0.80 | KMT2A (0.51) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL14966407 | 0.80 | TAAR1 (0.35) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14966956 | 0.77 | CYP4A11 (0.49) | KMT2AMEN1 | |
| SCHEMBL19859011 | 0.75 | ALDH1A1 (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL19859012 | 0.75 | ALDH1A1 (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL19859013 | 0.75 | ALDH1A1 (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7142115 | 0.74 | MEN1 (0.41) | PDE4DPDE4APDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |