Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967524 | 0.86 | KMT2A (0.59) | KMT2ASRD5A2LTB4RLTB4R2ALOX5 | |
| SCHEMBL10148419 | 0.86 | KMT2A (0.65) | KMT2ASRD5A2LTB4RLTB4R2ALOX5 | |
| SCHEMBL8782592 | 0.86 | KMT2A (0.65) | KMT2ASRD5A2LTB4RLTB4R2ALOX5 | |
| SCHEMBL10148418 | 0.86 | KMT2A (0.65) | KMT2ASRD5A2LTB4RLTB4R2ALOX5 | |
| SCHEMBL14966382 | 0.86 | KMT2A (0.59) | KMT2ASRD5A2LTB4RLTB4R2ALOX5 | |
| SCHEMBL14967363 | 0.85 | PPARA (0.59) | KMT2AALDH1A1SRD5A2LTB4RLTB4R2 | |
| SCHEMBL20370928 | 0.85 | SRD5A2 (0.66) | KMT2AALDH1A1SMN1; SMN2SRD5A2MEN1 | |
| SCHEMBL9102528 | 0.84 | KMT2A (0.85) | KMT2AALDH1A1SMN1; SMN2SRD5A2MEN1 | |
| SCHEMBL14967257 | 0.84 | MEN1 (0.68) | KMT2AALDH1A1SMN1; SMN2LTB4RLTB4R2 | |
| SCHEMBL14967540 | 0.83 | RXRA (0.52) | KMT2AALDH1A1SMN1; SMN2SRD5A2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |