Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 2/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | THPO | P40225 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GNPAT | O15228 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19479440 | 1.00 | HIF1A (0.42) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL19392167 | 0.81 | HIF1A (0.39) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL23752015 | 0.80 | HIF1A (0.42) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL14831398 | 0.80 | HIF1A (0.42) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL15914159 | 0.80 | HIF1A (0.42) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL11428513 | 0.80 | HIF1A (0.42) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL13091636 | 0.79 | ALDH1A1 (0.38) | ALDH1A1CA2FAPPREPKDM4E | |
| SCHEMBL11100606 | 0.78 | DPP4 (0.50) | HIF1AALDH1A1CA2CA1FAP | |
| SCHEMBL21335951 | 0.78 | HIF1A (0.40) | HIF1AALDH1A1CA2CA1DPP4 | |
| SCHEMBL24336888 | 0.78 | HIF1A (0.40) | HIF1AALDH1A1CA2CA1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780322-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | Ligand Pharmaceuticals Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074459-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | LIGAND PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | WO | disclosed |