Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966398 | 0.94 | POLB (0.52) | POLBHPGDHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14966965 | 0.89 | NPC1 (0.47) | HPGDSMN1; SMN2KLKB1LMNAHSD17B10 | |
| SCHEMBL14966659 | 0.85 | LMNA (0.48) | POLBHPGDSMN1; SMN2KLKB1LMNA | |
| SCHEMBL14966598 | 0.85 | KLKB1 (0.44) | POLBKLKB1ROCK2CYP3A4CYP2D6 | |
| SCHEMBL14966541 | 0.85 | LMNA (0.41) | POLBHPGDKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL14966778 | 0.84 | NPC1 (0.49) | POLBHTTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14969436 | 0.82 | MAPK14 (0.44) | KDM4ESMN1; SMN2ALDH1A1KLKB1 | |
| SCHEMBL14966830 | 0.81 | KLKB1 (0.44) | KDM4ESMN1; SMN2ALDH1A1KLKB1 | |
| SCHEMBL14966798 | 0.81 | KLKB1 (0.44) | POLBHTTSMN1; SMN2ALDH1A1KLKB1 | |
| SCHEMBL14967113 | 0.81 | LMNA (0.50) | HTTSMN1; SMN2ROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |