SCHEMBL14967280

SCHEMBL14967280

CCCCCCCCCCCCC(=O)O[C@@H](CO)C(OP(=O)([O-])OCC[N+](C)(C)C)C(=O)CCCCCCCCCCC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.59
NR5A2 O00482 1/20 0.59
NR5A1 Q13285 1/20 0.59
RECQL P46063 1/20 0.57
MAPT P10636 1/20 0.54
LMNA P02545 1/20 0.53
ESR1 P03372 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
CDC25A P30304 1/20 0.53
AGTR1 P30556 1/20 0.53
AKT1 P31749 1/20 0.53
ADRA1A P35348 1/20 0.53
KCNH2 Q12809 1/20 0.53
ALDH1A1 P00352 1/20 0.51
ADRA1D P25100 1/20 0.50
PTAFR P25105 1/20 0.50
HTR1D P28221 1/20 0.50
HTR2C P28335 1/20 0.50
ADRA1B P35368 1/20 0.50
DRD3 P35462 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7753858 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL479274 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL479199 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL672865 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL671970 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL479150 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL673766 1.00 SMN1; SMN2 (0.59) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL2930405 0.96 SMN1; SMN2 (0.55) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL37559 0.94 ALDH1A1 (0.60) SMN1; SMN2NR5A2NR5A1RECQLMAPT
SCHEMBL672371 0.94 ALDH1A1 (0.60) SMN1; SMN2NR5A2NR5A1RECQLMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015073396-A1 GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC HEART FAILURE THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2015-05-21 WO disclosed
EP-2828289-A1 GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC HEART FAILURE The Brigham and Women's Hospital, Inc. (US) 2015-01-28 EP disclosed
WO-2013142114-A1 GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC HEART FAILURE THE BRIGHAM AND WOMEN'S HOSPTIAL, INC. (US) 2013-09-26 WO disclosed
WO-2013074583-A1 TREATMENT AND PROGNOSIS OF LYMPHANGIOLEIOMYOMATOSIS THE BROAD INSTITUTE, INC. (US) 2013-05-23 WO disclosed