Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965266 | 0.94 | KMT2A (0.50) | KMT2APOLBHTTLMNAMEN1 | |
| SCHEMBL16293357 | 0.92 | LMNA (0.56) | KMT2APOLBHTTLMNAMEN1 | |
| SCHEMBL16293147 | 0.82 | LMNA (0.51) | KMT2APOLBHTTLMNAMEN1 | |
| SCHEMBL14965107 | 0.80 | POLB (0.52) | KMT2APOLBHTTLMNA | |
| SCHEMBL14965498 | 0.77 | POLB (0.52) | KMT2APOLBHTTLMNAADRB2 | |
| SCHEMBL14965110 | 0.76 | POLB (0.56) | KMT2APOLBHTTLMNA | |
| SCHEMBL16294151 | 0.76 | POLB (0.55) | KMT2APOLBHTTLMNA | |
| SCHEMBL14968920 | 0.75 | SMN1; SMN2 (0.34) | SMN1; SMN2 | |
| SCHEMBL16293617 | 0.75 | SMN1; SMN2 (0.41) | KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL14965219 | 0.75 | KMT2A (0.50) | KMT2APOLBHTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |