Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 17/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969148 | 1.00 | DGAT1 (0.53) | DGAT1KCNH2SOAT1ALOX5APFEN1 | |
| SCHEMBL14969147 | 1.00 | DGAT1 (0.53) | DGAT1KCNH2SOAT1ALOX5APFEN1 | |
| SCHEMBL14971870 | 0.94 | DGAT1 (0.46) | DGAT1KCNH2SOAT1ADORA2A | |
| SCHEMBL14969212 | 0.90 | DGAT1 (0.52) | DGAT1KCNH2SOAT1ADORA2A | |
| SCHEMBL14969271 | 0.90 | DGAT1 (0.52) | DGAT1KCNH2SOAT1ADORA2A | |
| SCHEMBL14971844 | 0.90 | DGAT1 (0.52) | DGAT1KCNH2SOAT1ADORA2A | |
| SCHEMBL14969256 | 0.89 | DGAT1 (0.45) | DGAT1KCNH2SOAT1ALOX5APFEN1 | |
| SCHEMBL14971296 | 0.86 | DGAT1 (0.71) | DGAT1KCNH2SOAT1ADORA2AATR | |
| SCHEMBL14971276 | 0.86 | DGAT1 (0.71) | DGAT1KCNH2SOAT1ADORA2AATR | |
| SCHEMBL14971677 | 0.86 | DGAT1 (0.64) | DGAT1KCNH2SOAT1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |