Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971567 | 0.82 | DGAT1 (0.57) | DGAT1KDM4ERAB9AMAPTCPB2 | |
| SCHEMBL14971934 | 0.82 | DGAT1 (0.57) | DGAT1KDM4ERAB9AMAPTCPB2 | |
| SCHEMBL14968100 | 0.82 | DGAT1 (0.57) | DGAT1KDM4ERAB9AMAPTCPB2 | |
| SCHEMBL14968065 | 0.79 | DGAT1 (0.50) | DGAT1KDM4EMAPTHSD11B1MAPK1 | |
| SCHEMBL669097 | 0.79 | DGAT1 (0.50) | DGAT1KDM4EMAPTHSD11B1MAPK1 | |
| SCHEMBL14968084 | 0.79 | DGAT1 (0.50) | DGAT1KDM4EMAPTHSD11B1MAPK1 | |
| SCHEMBL14967794 | 0.77 | DGAT1 (0.51) | DGAT1KDM4ERAB9AMAPTHCRTR2 | |
| SCHEMBL14967861 | 0.77 | DGAT1 (0.48) | DGAT1KDM4EMAPTHCRTR2MAPK1 | |
| SCHEMBL22907265 | 0.76 | DGAT1 (0.43) | DGAT1KDM4ERAB9AMAPTHCRTR2 | |
| SCHEMBL29547742 | 0.76 | DGAT1 (0.43) | DGAT1KDM4ERAB9AMAPTHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |