Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966982 | 1.00 | PPARA (0.45) | PPARAHPGDLMNAHSD17B10MAPT | |
| SCHEMBL14969773 | 1.00 | PPARA (0.45) | PPARAHPGDLMNAHSD17B10MAPT | |
| SCHEMBL14972144 | 0.92 | SMN1; SMN2 (0.42) | HPGDMAPTTP53CYP3A4MAPK14 | |
| SCHEMBL14967050 | 0.90 | KLKB1 (0.46) | PPARAHPGDLMNAHSD17B10MAPT | |
| SCHEMBL14966658 | 0.90 | SMN1; SMN2 (0.45) | HPGDLMNAHSD17B10MAPTTP53 | |
| SCHEMBL14967419 | 0.90 | SMN1; SMN2 (0.45) | HPGDLMNAHSD17B10MAPTTP53 | |
| SCHEMBL14967406 | 0.90 | SMN1; SMN2 (0.45) | HPGDLMNAHSD17B10MAPTTP53 | |
| SCHEMBL14967264 | 0.89 | SMN1; SMN2 (0.42) | HPGDLMNATP53CYP3A4MAPK14 | |
| SCHEMBL14972250 | 0.89 | KLKB1 (0.43) | HPGDLMNAHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL14966574 | 0.89 | KLKB1 (0.43) | HPGDLMNAHSD17B10SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |