Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.62 |
| ▸ | AXL | P30530 | 5/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.58 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | MST1R | Q04912 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14970945 | 0.91 | MET (0.64) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971040 | 0.91 | MET (0.64) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970975 | 0.91 | MET (0.64) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970961 | 0.91 | MET (0.63) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970970 | 0.91 | MET (0.66) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971033 | 0.90 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970926 | 0.90 | MET (0.64) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970981 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971034 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970954 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074633-A1 | URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS | CEPHALON, INC. (US) | 2013-05-23 | — | — | WO | disclosed |