Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.61 |
| ▸ | AXL | P30530 | 5/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971041 | 0.96 | MET (0.61) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970970 | 0.92 | MET (0.66) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971028 | 0.91 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971033 | 0.90 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971027 | 0.90 | MET (0.61) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971008 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971034 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970954 | 0.89 | MET (0.62) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14970945 | 0.89 | MET (0.64) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL14971040 | 0.89 | MET (0.64) | METAXLKDRPDGFRAMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074633-A1 | URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS | CEPHALON, INC. (US) | 2013-05-23 | — | — | WO | disclosed |