Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.63 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.61 |
| ▸ | FLT3 | P36888 | 4/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.61 |
| ▸ | FLT1 | P17948 | 2/20 | 0.61 |
| ▸ | MST1R | Q04912 | 2/20 | 0.61 |
| ▸ | AXL | P30530 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971022 | 0.99 | MET (0.64) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970968 | 0.94 | MET (0.68) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14971058 | 0.90 | MET (0.57) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970976 | 0.89 | MET (0.61) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970945 | 0.89 | MET (0.64) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970975 | 0.89 | MET (0.64) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14971040 | 0.89 | MET (0.64) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970970 | 0.88 | MET (0.66) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14970961 | 0.88 | MET (0.63) | METKDRKITFLT3PDGFRB | |
| SCHEMBL14971033 | 0.87 | MET (0.62) | METKDRKITFLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074633-A1 | URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS | CEPHALON, INC. (US) | 2013-05-23 | — | — | WO | disclosed |