Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 10/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231224 | 0.90 | HDAC4 (0.47) | UTS2RROCK2ROCK1HDAC4MEF2D | |
| SCHEMBL1482305 | 0.88 | UTS2R (0.43) | UTS2RROCK2ROCK1HDAC2 | |
| SCHEMBL1496979 | 0.88 | UTS2R (0.47) | UTS2RROCK2ROCK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1497060 | 0.87 | UTS2R (0.47) | UTS2RROCK2ROCK1KMT2AHDAC1 | |
| SCHEMBL1496896 | 0.87 | UTS2R (0.47) | UTS2RROCK2ROCK1HDAC3HDAC1 | |
| SCHEMBL1497125 | 0.86 | NAMPT (0.42) | UTS2RROCK2ROCK1RAB9ANPC1 | |
| SCHEMBL1496973 | 0.86 | UTS2R (0.47) | UTS2RROCK2ROCK1RAB9ANPC1 | |
| SCHEMBL1497138 | 0.86 | UTS2R (0.46) | UTS2RROCK2ROCK1 | |
| SCHEMBL1497187 | 0.86 | UTS2R (0.42) | UTS2RROCK2ROCK1 | |
| SCHEMBL1497004 | 0.85 | UTS2R (0.62) | UTS2RROCK2ROCK1HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |