Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 11/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385344 | 0.91 | UTS2R (0.64) | UTS2RGRM4HDAC1ROCK2ROCK1 | |
| SCHEMBL1496979 | 0.90 | UTS2R (0.47) | UTS2RROCK2ROCK1AURKAALDH1A1 | |
| SCHEMBL1496896 | 0.89 | UTS2R (0.47) | UTS2RHDAC1ROCK2ROCK1AURKA | |
| SCHEMBL1497068 | 0.89 | UTS2R (0.47) | UTS2RROCK2ROCK1ALDH1A1 | |
| SCHEMBL1497138 | 0.88 | UTS2R (0.46) | UTS2RROCK2ROCK1 | |
| SCHEMBL11899970 | 0.88 | UTS2R (0.59) | UTS2RGRM4THRBROCK2ROCK1 | |
| SCHEMBL1497151 | 0.85 | UTS2R (0.42) | UTS2RHDAC1ROCK2ROCK1ALDH1A1 | |
| SCHEMBL1496973 | 0.85 | UTS2R (0.47) | UTS2RHDAC1ROCK2ROCK1ALDH1A1 | |
| SCHEMBL1482305 | 0.85 | UTS2R (0.43) | UTS2RROCK2ROCK1 | |
| SCHEMBL1497089 | 0.85 | UTS2R (0.42) | UTS2RROCK2ROCK1AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |