Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1099809 | 0.97 | TRPV1 (0.43) | TRPV1RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL1099807 | 0.90 | DGAT1 (0.38) | TRPV1RAF1MAPTSMN1; SMN2STAT3 | |
| SCHEMBL1100633 | 0.89 | RAF1 (0.43) | TRPV1RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL1099653 | 0.88 | CNR2 (0.41) | TRPV1MAPTSMN1; SMN2KDM4EDGAT1 | |
| SCHEMBL1100554 | 0.88 | TRPV1 (0.47) | TRPV1MAPTKDM4EDGAT1KCNQ3 | |
| SCHEMBL1101169 | 0.88 | TRPV1 (0.43) | TRPV1RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL1101330 | 0.87 | DGAT1 (0.41) | TRPV1MAPTSMN1; SMN2DGAT1FASN | |
| SCHEMBL1100063 | 0.86 | TRPV1 (0.49) | TRPV1RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL1100911 | 0.85 | CNR2 (0.41) | TRPV1MAPTDGAT1FASNKCNQ3 | |
| SCHEMBL1099691 | 0.83 | TRPV1 (0.43) | TRPV1RAF1BRAFMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125811-B1 | N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES DERIVATIVES, PREPARATION THEREOF AND THEIR USE IN THERAPY | SANOFI SA (FR) | 2013-05-29 | — | — | EP | disclosed |