Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.80 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973624 | 1.00 | CTSS (0.80) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL16726411 | 0.99 | CTSS (0.81) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL25524332 | 0.99 | CTSS (0.81) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL25524201 | 0.94 | CTSS (0.73) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL2213580 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL2213583 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL2216261 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL12349978 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL2213587 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL2216257 | 0.93 | CTSS (0.75) | CTSSADRB3ADRA2BADRA2CCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785875-B1 | A SINGLE NUCLEOTIDE POLYMORPHISM ON CHROMOSOME 15 THAT PREDICTS HCV TREATMENT RESPONSES | HOFFMANN LA ROCHE (CH) | 2016-04-27 | — | — | EP | disclosed |
| EP-2785875-A1 | A SINGLE NUCLEOTIDE POLYMORPHISM ON CHROMOSOME 15 THAT PREDICTS HCV TREATMENT RESPONSES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079424-A1 | A SINGLE NUCLEOTIDE POLYMORPHISM ON CHROMOSOME 15 THAT PREDICTS HCV TREATMENT RESPONSES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-06 | — | — | WO | disclosed |
| US-20130137084-A1 | Single Nucleotide Polymorphism on Chromosome 15 That Predicts HCV Treatment Responses | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2013-05-30 | — | — | US | disclosed |