Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 13/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 15/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 11/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14974514 | 1.00 | RPS6KB1 (0.52) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL526995 | 0.94 | RPS6KB1 (0.47) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL526994 | 0.94 | RPS6KB1 (0.47) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974377 | 0.92 | AKT1 (0.54) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974378 | 0.92 | AKT1 (0.54) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527213 | 0.92 | AKT1 (0.46) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527214 | 0.92 | AKT1 (0.46) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527521 | 0.90 | RPS6KB1 (0.55) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527522 | 0.90 | RPS6KB1 (0.55) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL531309 | 0.90 | RPS6KB1 (0.55) | RPS6KB1AURKBAURKAAKT1INCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710044-B2 | Bicyclic azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-04-29 | — | — | US | claimed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | claimed |
| US-8710044-B2 | Bicyclic azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-04-29 | — | — | US | disclosed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | CCNI, CCNA1, CCNA2 | RPS6KB1 731/4885AURKB 460/4885AURKA 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.