Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 14/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 13/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 11/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526995 | 1.00 | RPS6KB1 (0.47) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974532 | 0.96 | RPS6KB1 (0.50) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974536 | 0.96 | RPS6KB1 (0.50) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974516 | 0.94 | RPS6KB1 (0.52) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14974514 | 0.94 | RPS6KB1 (0.52) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527005 | 0.88 | AKT1 (0.45) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14975120 | 0.88 | AKT1 (0.52) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527004 | 0.88 | AKT1 (0.45) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL14975121 | 0.88 | AKT1 (0.52) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL527633 | 0.86 | RPS6KB1 (0.53) | RPS6KB1AURKBAURKAAKT1INCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | claimed |
| WO-2012013282-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | claimed |