Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976522 | 0.90 | GPR119 (0.38) | GPR119PRMT1MAPTMEN1KMT2A | |
| SCHEMBL14975840 | 0.87 | CA1 (0.48) | GPR119PRMT1CA1CA2CA7 | |
| SCHEMBL14976833 | 0.83 | MAPT (0.40) | GPR119PRMT1MAPTMEN1KMT2A | |
| SCHEMBL14976238 | 0.80 | KMT2A (0.35) | GPR119PRMT1MAPTMEN1KMT2A | |
| SCHEMBL14976306 | 0.79 | SYK (0.36) | MEN1KMT2ASYK | |
| SCHEMBL14976585 | 0.79 | SYK (0.42) | MEN1KMT2ASYK | |
| SCHEMBL14976387 | 0.79 | SYK (0.42) | MEN1KMT2ASYK | |
| SCHEMBL14976237 | 0.77 | GPR119 (0.37) | GPR119PRMT1MEN1KMT2ASYK | |
| SCHEMBL14975697 | 0.76 | GSK3B (0.37) | GPR119MAPTMEN1KMT2AGSK3A | |
| SCHEMBL14975788 | 0.76 | KMT2A (0.40) | GPR119PRMT1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078254-A1 | BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-05-30 | — | — | WO | disclosed |