Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.70 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975932 | 0.89 | SYK (0.72) | SYKZAP70KCNH2AURKBMAPK3 | |
| SCHEMBL4716047 | 0.83 | SYK (1.00) | SYKZAP70MAPK8KCNH2AURKB | |
| SCHEMBL2714938 | 0.81 | SYK (0.48) | SYKZAP70MAPK8KCNH2AURKB | |
| SCHEMBL1354389 | 0.78 | SYK (0.77) | SYKZAP70KCNH2AURKB | |
| SCHEMBL2627126 | 0.77 | MAPK8 (0.69) | SYKZAP70MAPK8KCNH2AURKB | |
| SCHEMBL14976169 | 0.77 | SYK (0.72) | SYKZAP70 | |
| SCHEMBL14976172 | 0.77 | SYK (0.72) | SYKZAP70 | |
| SCHEMBL16195189 | 0.76 | SYK (0.59) | SYKZAP70MAPK8KCNH2AURKB | |
| SCHEMBL16195188 | 0.76 | SYK (0.59) | SYKZAP70MAPK8KCNH2AURKB | |
| SCHEMBL14981677 | 0.76 | SYK (0.59) | SYKZAP70MAPK8KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |