Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 1.00 |
| ▸ | ZAP70 | P43403 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1354236 | 0.89 | SYK (1.00) | SYKZAP70KCNH2AURKB | |
| SCHEMBL29794716 | 0.86 | SYK (1.00) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL2383949 | 0.86 | SYK (1.00) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14976169 | 0.84 | SYK (0.72) | SYKZAP70 | |
| SCHEMBL14976172 | 0.84 | SYK (0.72) | SYKZAP70 | |
| SCHEMBL14976220 | 0.83 | SYK (0.70) | SYKZAP70KCNH2AURKBMAPK8 | |
| SCHEMBL4712719 | 0.83 | SYK (0.77) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL29794597 | 0.83 | SYK (0.77) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL28110005 | 0.81 | MAPK8 (0.71) | SYKZAP70KCNH2AURKBMAPK8 | |
| SCHEMBL13733951 | 0.81 | SYK (0.69) | SYKZAP70KCNH2AURKBCAMK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054004-B1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-6432963-B1 | ANTIINFLAMMATORY AGENTS; TYROSINE KINASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1054004-A1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-11-22 | — | — | EP | disclosed |