Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977132 | 0.84 | EPHB3 (0.34) | SYKEPHB3JAK2JAK1JAK3 | |
| SCHEMBL14956467 | 0.81 | SYK (0.39) | SYKEPHB3JAK2JAK1JAK3 | |
| SCHEMBL14976405 | 0.81 | JAK2 (0.38) | SYKEPHB3JAK2JAK1JAK3 | |
| SCHEMBL14956465 | 0.81 | SYK (0.39) | SYKEPHB3JAK2JAK1JAK3 | |
| SCHEMBL14955499 | 0.73 | SYK (0.61) | SYKJAK2JAK3TYK2KCNH2 | |
| SCHEMBL14955804 | 0.72 | SYK (0.51) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14956138 | 0.72 | IRAK4 (0.46) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14956136 | 0.72 | IRAK4 (0.46) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14976282 | 0.70 | SYK (0.35) | SYKJAK2JAK3TYK2KCNH2 | |
| SCHEMBL14975825 | 0.70 | SYK (0.35) | SYKJAK2JAK3TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782579-A1 | PYRAZINE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |