Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 20/20 | 0.73 |
| ▸ | CTSB | P07858 | 17/20 | 0.69 |
| ▸ | CTSS | P25774 | 17/20 | 0.69 |
| ▸ | CTSK | P43235 | 17/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3079583 | 1.00 | CTSL (0.73) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3067312 | 0.96 | CTSL (0.68) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3078477 | 0.95 | CTSL (0.66) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3076278 | 0.92 | CTSL (0.73) | CTSLCTSBCTSSCTSK | |
| SCHEMBL14973560 | 0.92 | CTSL (0.73) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3060920 | 0.91 | CTSL (0.62) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3060809 | 0.90 | CTSL (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3071014 | 0.90 | CTSL (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3066405 | 0.90 | CTSL (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3064976 | 0.88 | CTSL (0.65) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782903-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013076063-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-30 | — | — | WO | disclosed |