Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057557 | 0.84 | CYP3A4 (0.47) | ASAH1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16057538 | 0.83 | MAPT (0.40) | ASAH1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL16057331 | 0.82 | DCTPP1 (0.43) | ALDH1A1KDM4EMAPTMEN1LMNA | |
| SCHEMBL28510085 | 0.81 | KDM4E (0.48) | GCGRHSD11B1ALDH1A1KDM4EMAPT | |
| SCHEMBL16057532 | 0.79 | MAPT (0.39) | ASAH1MAPT | |
| SCHEMBL16056895 | 0.75 | RARB (0.48) | HSD11B1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14975143 | 0.73 | BID (0.50) | KDM4EMAPT | |
| SCHEMBL14977312 | 0.73 | BID (0.50) | KDM4EMAPT | |
| SCHEMBL16058205 | 0.73 | BID (0.50) | KDM4EMAPT | |
| SCHEMBL16058319 | 0.73 | BID (0.50) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782567-A1 | DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) | The Regents of The University of California (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078430-A1 | DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-30 | — | — | WO | disclosed |