SCHEMBL14977765

SCHEMBL14977765

CNC(=O)c1c(-c2ccc(F)cc2)nc2sc(-c3cccc(C(=O)NC4(c5ccccn5)CC4)c3)cn12

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C8 P10632 3/20 0.47
KCNH2 Q12809 3/20 0.47
CYP3A4 P08684 2/20 0.47
NR1I2 O75469 1/20 0.47
ACKR3 P25106 1/20 0.37
ADORA2A P29274 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
DGAT2 Q96PD7 1/20 0.35
NAMPT P43490 1/20 0.35
OTUD7B Q6GQQ9 2/20 0.35
GUCY1B2 O75343 1/20 0.34
GUCY1A2 P33402 1/20 0.34
GUCY1A1 Q02108 1/20 0.34
GUCY1B1 Q02153 1/20 0.34
MAPK14 Q16539 1/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14977691 0.89 CYP2C8 (0.43) CYP2C8KCNH2CYP3A4NR1I2OTUD7B
SCHEMBL14977700 0.89 CYP2C8 (0.57) CYP2C8KCNH2CYP3A4NR1I2ACKR3
SCHEMBL14977582 0.87 CYP2C8 (0.41) CYP2C8KCNH2CYP3A4NR1I2ACKR3
SCHEMBL14986297 0.81 CYP2C8 (0.48) CYP2C8KCNH2CYP3A4NR1I2ADORA2A
SCHEMBL14977329 0.80 MAPT (0.47) MAPK14
SCHEMBL14977224 0.79 KIT (0.39) SMN1; SMN2
SCHEMBL1936129 0.78 CYP2C8 (0.60) CYP2C8KCNH2CYP3A4NR1I2ACKR3
SCHEMBL14986304 0.78 CYP2C8 (0.54) CYP2C8KCNH2CYP3A4NR1I2MAPK14
SCHEMBL9911908 0.75 CYP2C8 (0.51) CYP2C8KCNH2CYP3A4NR1I2ADORA2A
SCHEMBL14977630 0.75 CYP2C8 (0.52) CYP2C8KCNH2CYP3A4NR1I2MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013075173-A1 COMPOUNDS FOR THE TREATMENT OF HCV BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-05-30 WO disclosed
WO-2013075173-A1 COMPOUNDS FOR THE TREATMENT OF HCV BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-05-30 WO disclosed