Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14981799 | 0.91 | TBK1 (0.56) | TBK1IKBKETNIK | |
| SCHEMBL14977031 | 0.87 | TBK1 (0.62) | TBK1IKBKETNIK | |
| SCHEMBL14976315 | 0.85 | TBK1 (0.70) | TBK1IKBKE | |
| SCHEMBL14981942 | 0.84 | TBK1 (0.70) | TBK1IKBKE | |
| SCHEMBL19638558 | 0.83 | TBK1 (0.45) | TBK1IKBKE | |
| SCHEMBL14977423 | 0.82 | TBK1 (0.44) | TBK1IKBKE | |
| SCHEMBL16194552 | 0.81 | TBK1 (0.55) | TBK1IKBKE | |
| SCHEMBL14977054 | 0.81 | TBK1 (0.68) | TBK1 | |
| SCHEMBL14976939 | 0.81 | TNIK (0.59) | TBK1IKBKETNIK | |
| SCHEMBL19119400 | 0.80 | IKBKE (0.76) | TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| EP-2794602-A1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |