Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10201440 | 0.80 | AURKA (0.34) | AURKAPIM1ROCK1CLK4PIK3CD | |
| SCHEMBL5311516 | 0.74 | AURKA (0.37) | AURKAPIM1ROCK1CLK4CSNK1A1 | |
| SCHEMBL23089173 | 0.74 | GRM5 (0.37) | AURKAPIM1ROCK1CLK4CSNK1A1 | |
| SCHEMBL29987052 | 0.70 | MKNK2 (0.41) | AURKAPIM1ROCK1CLK4PIK3CD | |
| SCHEMBL1476404 | 0.70 | MKNK2 (0.41) | AURKAPIM1ROCK1CLK4CSNK1A1 | |
| SCHEMBL24667786 | 0.70 | MKNK2 (0.41) | AURKAPIM1ROCK1CLK4PIK3CD | |
| SCHEMBL4729863 | 0.70 | AURKA (0.44) | AURKAPIM1ROCK1CLK4DYRK1B | |
| SCHEMBL10200890 | 0.70 | AURKA (0.34) | AURKAKDRCDK1CA12CA9 | |
| SCHEMBL32666473 | 0.70 | GAA (0.43) | PIM1MAOAMAOBKDRABCC9 | |
| SCHEMBL25302444 | 0.68 | KDR (0.41) | AURKAPIM1ROCK1CLK4CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | TNF, ADAMTS13, MMP11 | AURKA 1956/4885PIM1 4393/4885ROCK1 1828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.