Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748007 | 0.81 | ALDH1A1 (0.62) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL12376549 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL7747114 | 0.79 | ALDH1A1 (0.66) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL2282322 | 0.79 | ALDH1A1 (0.60) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL7746971 | 0.79 | ALDH1A1 (0.66) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL8023138 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL2924557 | 0.75 | ALDH1A1 (0.70) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL10223654 | 0.73 | ALDH1A1 (0.74) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL6191426 | 0.72 | ALDH1A1 (0.73) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 | |
| SCHEMBL19010425 | 0.72 | ALDH1A1 (0.61) | ALDH1A1TDP1KDM4ENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |