Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235868 | 0.85 | CA1 (0.49) | CTSKSLC18A3CA1CA2CA4 | |
| SCHEMBL612081 | 0.82 | SLC18A3 (0.39) | CTSKSLC18A3CA1CA2CA4 | |
| SCHEMBL11474308 | 0.75 | SLC18A3 (0.51) | CTSKSLC18A3CA1CA2CA4 | |
| SCHEMBL17891946 | 0.75 | CA1 (0.36) | CTSKSLC18A3CA1CA2CA4 | |
| SCHEMBL10235914 | 0.72 | CNR1 (0.43) | KMT2ACA1CA2CA4 | |
| SCHEMBL18440461 | 0.72 | SLC18A2 (0.54) | SLC18A3 | |
| SCHEMBL10235823 | 0.71 | CA1 (0.42) | CA1CA2CA4 | |
| SCHEMBL13862328 | 0.70 | MEN1 (0.78) | MEN1KMT2ANOS3NOS1L3MBTL1 | |
| SCHEMBL608470 | 0.69 | KCNH2 (0.44) | TAAR1 | |
| SCHEMBL11467209 | 0.69 | MEN1 (0.58) | MEN1KMT2ANOS3NOS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450527-B2 | Amine derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC. (US) | 2013-05-28 | — | — | US | disclosed |