Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15100374 | 0.91 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL14442980 | 0.91 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL14462379 | 0.89 | — | — | |
| SCHEMBL14964264 | 0.86 | MAPK1 (0.30) | MAPTMAPK1 | |
| SCHEMBL14964262 | 0.86 | MAPK1 (0.30) | MAPTMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5630925 | 0.86 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL5630928 | 0.86 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL15100554 | 0.83 | MEN1 (0.34) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL14980210 | 0.82 | CYP1A2 (0.37) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14442981 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | disclosed |