SCHEMBL14980745

SCHEMBL14980745

CC[C@@H](CCO[Si](C)(C)C(C)(C)C)OCc1ccc(OC)cc1

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.40
AGXT P21549 2/20 0.40
TBXAS1 P24557 10/20 0.39
APLNR P35414 1/20 0.35
APP P05067 5/20 0.35
FFAR1 O14842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23648276 0.88 IDO1 (0.38) IDO1AGXTTBXAS1APLNRAPP
SCHEMBL23648273 0.85 IDO1 (0.36) IDO1AGXTTBXAS1APLNRAPP
SCHEMBL17305608 0.84 TBXAS1 (0.35) IDO1AGXTTBXAS1APLNRAPP
SCHEMBL10100263 0.84 TBXAS1 (0.35) IDO1AGXTTBXAS1APLNRAPP
SCHEMBL10100258 0.82 MEN1 (0.37) IDO1AGXTTBXAS1APLNRFFAR1
SCHEMBL17305607 0.82 MEN1 (0.37) IDO1AGXTTBXAS1APLNRFFAR1
SCHEMBL29770026 0.81 CNR1 (0.40) IDO1AGXTTBXAS1
SCHEMBL12047343 0.80 HDAC2 (0.36) IDO1AGXTTBXAS1
SCHEMBL14587571 0.77 TBXAS1 (0.45) TBXAS1
SCHEMBL12047342 0.73 HDAC2 (0.46) IDO1AGXTTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2597091-A1 Antitumoral Compounds PHARMA MAR, S.A. (ES) 2013-05-29 EP disclosed