Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10631858 | 1.00 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL10629670 | 0.90 | CYP2C19 (0.61) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL10629322 | 0.87 | CYP2C19 (0.58) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL21120353 | 0.87 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL22426031 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL20719974 | 0.85 | CA12 (0.53) | MEN1KMT2ALMNAADRA2AADRA1A | |
| SCHEMBL10635852 | 0.84 | KMT2A (0.53) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL2205133 | 0.81 | HIF1A (0.58) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL10636013 | 0.81 | KMT2A (0.49) | ALDH1A1MEN1KMT2AMAPTTHRB | |
| SCHEMBL12428893 | 0.81 | KMT2A (0.49) | ALDH1A1MEN1KMT2AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |