Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | GRK5 | P34947 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12429331 | 0.89 | IGF1R (0.75) | IGF1RPTK2MAPK8MAPK10INSR | |
| SCHEMBL12429358 | 0.81 | IGF1R (0.90) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL12429374 | 0.80 | PTK2 (0.69) | IGF1RPTK2MAPK8MAPK10INSR | |
| SCHEMBL12429284 | 0.79 | IGF1R (0.85) | IGF1RPTK2MAPK8MAPK10INSR | |
| SCHEMBL12429321 | 0.79 | IGF1R (1.00) | IGF1RPTK2MAPK8MAPK10INSR | |
| SCHEMBL12429379 | 0.78 | PTK2 (0.85) | IGF1RPTK2MAPK8MAPK10INSR | |
| SCHEMBL18696331 | 0.77 | TTK (0.63) | IGF1RPTK2ALK | |
| SCHEMBL12430025 | 0.73 | IGF1R (0.81) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL18018944 | 0.72 | SRC (0.69) | PTK2 | |
| SCHEMBL11919325 | 0.71 | PTK2 (0.84) | IGF1RPTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |