Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 1.00 |
| ▸ | CDK4 | P11802 | 4/20 | 0.69 |
| ▸ | CCND1 | P24385 | 4/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.69 |
| ▸ | PRKCG | P05129 | 2/20 | 0.69 |
| ▸ | PRKCB | P05771 | 2/20 | 0.69 |
| ▸ | PRKCA | P17252 | 2/20 | 0.69 |
| ▸ | PRKCH | P24723 | 2/20 | 0.69 |
| ▸ | PRKCI | P41743 | 2/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.69 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14498921 | 0.85 | PARP1 (0.74) | PARP1CDK4CCND1CDK5CDK5R1 | |
| Staurosporine Aglycon SCHEMBL8124103 | 0.83 | CDK4 (1.00) | PARP1CDK4CCND1CDK5CDK5R1 | |
| Staurosporine Aglycon SCHEMBL30530825 | 0.83 | CDK4 (1.00) | PARP1CDK4CCND1CDK5CDK5R1 | |
| Staurosporine Aglycon SCHEMBL29406635 | 0.83 | CDK4 (1.00) | PARP1CDK4CCND1CDK5CDK5R1 | |
| SCHEMBL14346099 | 0.80 | PARP1 (0.66) | PARP1CDK4CCND1CHEK1 | |
| SCHEMBL12846165 | 0.80 | PARP1 (0.66) | PARP1CDK4CCND1PRKD3PRKCG | |
| SCHEMBL29435084 | 0.78 | PARP1 (1.00) | PARP1 | |
| SCHEMBL12256417 | 0.78 | PARP1 (1.00) | PARP1 | |
| SCHEMBL14356188 | 0.78 | MAP3K9 (0.82) | PARP1CDK4CCND1CDK5CDK5R1 | |
| SCHEMBL14708731 | 0.77 | CDK4 (0.80) | PARP1CDK4CCND1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066324-B1 | CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS | CEPHALON INC (US) | 2013-05-29 | — | — | EP | disclosed |