Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 1.00 |
| ▸ | CCND1 | P24385 | 13/20 | 1.00 |
| ▸ | CCNE2 | O96020 | 8/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 8/20 | 1.00 |
| ▸ | CDK2 | P24941 | 8/20 | 1.00 |
| ▸ | CAMK2B | Q13554 | 7/20 | 1.00 |
| ▸ | CAMK2G | Q13555 | 7/20 | 1.00 |
| ▸ | CAMK2D | Q13557 | 7/20 | 1.00 |
| ▸ | CAMK2A | Q9UQM7 | 7/20 | 1.00 |
| ▸ | CCNB2 | O95067 | 5/20 | 1.00 |
| ▸ | CDK1 | P06493 | 5/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 5/20 | 1.00 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 3/20 | 1.00 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 1.00 |
| ▸ | PRKACA | P17612 | 2/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 2/20 | 1.00 |
| ▸ | PRKACG | P22612 | 2/20 | 1.00 |
| ▸ | PRKACB | P22694 | 2/20 | 1.00 |
| ▸ | PRKCG | P05129 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Staurosporine Aglycon SCHEMBL29406635 | 1.00 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL30530825 | 1.00 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14708731 | 0.89 | CDK4 (0.80) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8127691 | 0.87 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL1395043 | 0.86 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL22566985 | 0.86 | CDK4 (0.74) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL29511391 | 0.86 | GLI1 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL9262153 | 0.86 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Granulatimide SCHEMBL4238896 | 0.84 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14980870 | 0.83 | PARP1 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630242-B1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | WELLCOME FOUND (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | claimed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | claimed |
| US-20230094365-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | SNAP BIO, INC. | 2023-03-30 | — | — | US | disclosed |
| US-11319320-B2 | PIM kinase inhibitor compositions, methods, and uses thereof | SNAP BIO, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-11319320-B2 | PIM kinase inhibitor compositions, methods, and uses thereof | SNAP BIO, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-20200331914-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | SNAP BIO, INC. | 2020-10-22 | — | — | US | disclosed |
| US-20200331914-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | SNAP BIO, INC. | 2020-10-22 | — | — | US | disclosed |
| EP-3706735-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | Snap Bio, Inc. (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3184537-B1 | GLYCOSYLATED INDOLOCARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF | UNIV OVIEDO (ES) | 2020-07-08 | — | — | EP | disclosed |
| US-10166241-B2 | Combination Therapy III | TURUN YLIOPISTO (FI) | 2019-01-01 | — | — | US | disclosed |
| EP-0642513-A1 | INDOLOCARBAZOLE IMIDES AND THEIR USE | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1995-03-15 | — | — | EP | disclosed |
| EP-0328000-B1 | Indolocarbazole derivatives, process for their preparation and medicines containing same | GOEDECKE AG (DE) | 1995-01-18 | — | — | EP | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993024491-A1 | INDOLOCARBAZOLE IMIDES AND THEIR USE | Gödecke Aktiengesellschaft (DE) | 1993-12-09 | — | — | WO | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |
| EP-0528030-A1 | ANTITUMOR BE-13793C DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |
| EP-0528030-A1 | ANTITUMOR BE-13793C DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991018003-A1 | ANTITUMOR BE-13793C DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-11-28 | — | — | WO | disclosed |
| EP-0328000-A2 | Indolocarbazole derivatives, process for their preparation and medicines containing same | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230094365-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | PIM1, PIM3, PIM2 | CDK4 198/4885CCND1 2406/4885CCNE2 3529/4885 |
| US-20200331914-A1 | PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES THEREOF | PIM1, PIM2, PIM3 | CDK4 221/4885CCND1 1985/4885CCNE2 2281/4885 |
| US-10166241-B2 | Combination Therapy III | HDAC4, HDAC3, HDAC5 | CDK4 68/4885CCND1 1174/4885CCNE2 1781/4885 |
| US-11319320-B2 | PIM kinase inhibitor compositions, methods, and uses thereof | PIM1, PIM2, PIM3 | CDK4 221/4885CCND1 1985/4885CCNE2 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.