Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14981966 | 0.98 | HCAR2 (0.42) | HCAR2KEAP1NFE2L2KDM4AKDM6B | |
| SCHEMBL14981965 | 0.95 | HCAR2 (0.45) | HCAR2KEAP1NFE2L2KDM4AKDM6B | |
| SCHEMBL14981964 | 0.79 | KDM4A (0.54) | KDM4AKDM6BKDM2AHIF1ATET2 | |
| SCHEMBL14981960 | 0.78 | KDM4A (0.54) | KDM4AKDM6BKDM2AKDM4E | |
| SCHEMBL14981962 | 0.77 | KDM4A (0.52) | KDM4AKDM6BKDM2AHIF1ATET2 | |
| SCHEMBL14985162 | 0.75 | KDM6B (0.77) | KDM4AKDM6BKDM2AKDM4ECHRM2 | |
| SCHEMBL17070792 | 0.74 | HCAR2 (0.54) | HCAR2KEAP1NFE2L2KDM4ESMN1; SMN2 | |
| SCHEMBL13296119 | 0.72 | HCAR2 (0.50) | HCAR2KEAP1NFE2L2KDM4ELMNA | |
| SCHEMBL14985134 | 0.71 | KDM6B (0.62) | KDM4AKDM6BKDM2AKDM4ESMN1; SMN2 | |
| SCHEMBL3463701 | 0.69 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2LMNAGFPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735622-B2 | Histone demethylase inhibitors and methods for using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735622-B2 | Histone demethylase inhibitors and methods for using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-05-27 | — | — | US | disclosed |
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | The Regents of the University of Colorado, a body corporated (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | The Regents of the University of Colorado, a body corporated (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | KDM1A, KDM3A, KDM7A | HCAR2 695/4885KEAP1 779/4885NFE2L2 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.