Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14981979 | 0.90 | KDM4E (0.47) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14985131 | 0.87 | KDM4E (0.50) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14981982 | 0.87 | NAMPT (0.42) | ALDH1A1MAPTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL14981981 | 0.82 | KDM4E (0.45) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14981980 | 0.80 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14985124 | 0.79 | KDM4E (0.55) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14985104 | 0.76 | KDM4E (0.61) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14985125 | 0.76 | KDM4E (0.65) | ALDH1A1MAPTKDM4ENPC1HPGD | |
| SCHEMBL14981983 | 0.74 | KDM6B (0.46) | KDM4ENPC1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL14981975 | 0.74 | KDM4E (0.62) | ALDH1A1KDM4ENPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735622-B2 | Histone demethylase inhibitors and methods for using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735622-B2 | Histone demethylase inhibitors and methods for using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-05-27 | — | — | US | disclosed |
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | The Regents of the University of Colorado, a body corporated (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | The Regents of the University of Colorado, a body corporated (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | KDM1A, KDM3A, KDM7A | ALDH1A1 837/4885MAPT 2972/4885KDM4E 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.