Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | PRKCI | P41743 | 7/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955659 | 0.90 | SYK (0.51) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL14955662 | 0.90 | SYK (0.51) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL14955573 | 0.78 | SYK (0.68) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL14955572 | 0.78 | SYK (0.68) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL14961934 | 0.76 | BTK (0.54) | SYKKCNH2MAPK1PRKCIROCK2 | |
| SCHEMBL14955221 | 0.76 | BTK (0.54) | SYKKCNH2MAPK1PRKCIROCK2 | |
| SCHEMBL14955218 | 0.76 | BTK (0.54) | SYKKCNH2MAPK1PRKCIROCK2 | |
| SCHEMBL14976634 | 0.76 | SYK (0.76) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL14976632 | 0.76 | SYK (0.76) | SYKKCNH2MAPK1MAPK3AURKB | |
| SCHEMBL18296158 | 0.74 | BTK (0.49) | SYKKCNH2MAPK1MAPK3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |