Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | ROS1 | P08922 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955463 | 0.89 | SYK (0.72) | SYKLCKJAK3RETROS1 | |
| SCHEMBL14955621 | 0.80 | SYK (0.72) | SYKLCKJAK3RETROS1 | |
| SCHEMBL14956834 | 0.78 | SYK (0.57) | SYKLCKJAK3RETROS1 | |
| SCHEMBL16743191 | 0.77 | SYK (0.76) | SYKALKEML4KCNH2 | |
| SCHEMBL18884553 | 0.77 | JAK3 (0.65) | SYKLCKJAK3RETROS1 | |
| SCHEMBL14985256 | 0.77 | BTK (0.54) | SYKLCKJAK3RETROS1 | |
| SCHEMBL1353801 | 0.75 | SYK (1.00) | SYKALKEML4 | |
| SCHEMBL13405517 | 0.72 | PIM1 (0.57) | SYKLCKJAK3RETROS1 | |
| SCHEMBL2627076 | 0.71 | SYK (0.87) | SYKALKEML4 | |
| SCHEMBL14955156 | 0.71 | JAK2 (0.61) | SYKLCKJAK3RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |