Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14956590 | 0.88 | LRRK2 (0.70) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14956506 | 0.82 | IRAK4 (0.53) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14985275 | 0.77 | LRRK2 (0.57) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14955736 | 0.77 | LRRK2 (0.67) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14985254 | 0.77 | SYK (0.60) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14985252 | 0.75 | BTK (0.43) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL14956176 | 0.75 | SYK (0.57) | BTKLCKLRRK2JAK2CDC7 | |
| SCHEMBL18925470 | 0.74 | SYK (0.58) | LRRK2JAK2ROCK2MAP4K4HCK | |
| SCHEMBL9107397 | 0.74 | SYK (0.68) | LRRK2JAK2ROCK2MAP4K4HCK | |
| SCHEMBL23080603 | 0.74 | SYK (0.54) | BTKLCKLRRK2JAK2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |