Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955736 | 0.91 | LRRK2 (0.67) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL18925760 | 0.87 | SYK (0.54) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL18925761 | 0.80 | SYK (0.49) | FERMAPK1SYKKCNH2 | |
| SCHEMBL14956590 | 0.80 | LRRK2 (0.70) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL20613169 | 0.78 | SYK (0.43) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL2728957 | 0.78 | SYK (0.64) | LRRK2JAK2ROCK2MAP4K4HCK | |
| SCHEMBL14955764 | 0.78 | LRRK2 (0.67) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL14985278 | 0.78 | PIK3CA (0.41) | LRRK2CHEK2CDC7PLK4CHEK1 | |
| SCHEMBL14839231 | 0.78 | SYK (0.76) | SYKKCNH2 | |
| SCHEMBL14985256 | 0.77 | BTK (0.54) | LRRK2CHEK2CDC7PLK4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |