Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441842 | 0.94 | TSHR (0.68) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL14987375 | 0.87 | TSHR (0.79) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL9120044 | 0.85 | NPSR1 (0.74) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL14987372 | 0.84 | TSHR (0.75) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL9120916 | 0.84 | TSHR (0.75) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL14986926 | 0.84 | NPSR1 (1.00) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL14986931 | 0.84 | TSHR (0.63) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL5363492 | 0.84 | TSHR (0.74) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL7934386 | 0.84 | TSHR (0.69) | TSHRHSD17B10NPSR1HPGDKDM4E | |
| SCHEMBL16186974 | 0.83 | TSHR (0.53) | TSHRHSD17B10NPSR1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10660789-B2 | 1,4-dihydropyridine derivatives with HSP modulating activity | RICHTER GEDEON NYRT. (HU) | 2020-05-26 | — | — | US | disclosed |
| US-20190192336-A1 | 1,4-Dihydropyridine Derivatives With HSP Modulating Activity | LIPIDART KUTATÓ FEJLESZTO ÉS TANÁCSADÓ KFT. (HU) | 2019-06-27 | — | — | US | disclosed |
| US-10258498-B2 | 1,4-dihydropyridine derivatives with Hsp modulating activity | RICHTER GEDEON NYRT. (HU) | 2019-04-16 | — | — | US | disclosed |
| US-20140315893-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | RICHTER GEDEON NYRT. (HU) | 2014-10-23 | — | — | US | disclosed |
| WO-2013076516-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | LIPIDART KUTATÓ FEJLESZTŐ ÉS TANÁCSADÓ KFT. (HU) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315893-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885NPSR1 660/4885 |
| US-10258498-B2 | 1,4-dihydropyridine derivatives with Hsp modulating activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885NPSR1 660/4885 |
| US-10660789-B2 | 1,4-dihydropyridine derivatives with HSP modulating activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885NPSR1 660/4885 |
| US-20190192336-A1 | 1,4-Dihydropyridine Derivatives With HSP Modulating Activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885NPSR1 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.