Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.43 |
| ▸ | KDR | P35968 | 14/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 9/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987910 | 1.00 | MET (0.43) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL2533408 | 0.91 | MST1R (0.52) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL107202 | 0.90 | MST1R (0.51) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL107201 | 0.90 | MST1R (0.51) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL14987981 | 0.90 | MET (0.44) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL14987982 | 0.90 | MET (0.44) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL3433426 | 0.88 | MST1R (0.48) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL3433431 | 0.88 | MST1R (0.48) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL306985 | 0.84 | MET (0.46) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL2533410 | 0.83 | MET (0.39) | METKDRAXLFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455484-B2 | Selected inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2013-06-04 | — | — | US | disclosed |