Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14989120 | 0.95 | AURKA (0.70) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989166 | 0.92 | AURKA (0.60) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989042 | 0.92 | AURKA (0.59) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989122 | 0.91 | AURKA (0.57) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989004 | 0.91 | AURKA (0.58) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989222 | 0.90 | AURKA (0.57) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL14989091 | 0.90 | AURKA (0.56) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL14989099 | 0.89 | AURKB (0.56) | AURKAAURKBCHEK1CDK5CDK5R1 | |
| SCHEMBL4313874 | 0.89 | AURKA (0.79) | AURKAAURKBCHEK1LTA4HCDK5 | |
| SCHEMBL4313866 | 0.89 | AURKA (0.79) | AURKAAURKBCHEK1LTA4HCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |